Hi Health practitioner Ben, I have a heterozygous mutation for your C677t and A1298, I commenced on 200mcg of 5mthf, then after a week moved as much as four hundred mcg and stayed on that for weekly or so. I then included one mg of methylb12 and experienced some adverse reactions. I'd serious upper body pain around my coronary heart and in the middle of my chest. Elevated heart price, when I would lie down I could really feel my coronary heart beat in all aspects of my human body. Sharp pain during the muscles of my arms shoulders and neck(as though I had been remaining stabbed by very small needles).
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I could consider 500mg Niacin and find out if this sensation shuts off. If it does, then probably I need to reduce my dose of B12 and/or TMG….
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